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Regulation of P-Glycoprotein in Renal Proximal Tubule Epithelial Cells by LPS and TNF-α
Joint Authors
Masereeuw, Rosalinde
Russel, Frans G. M.
Heemskerk, Suzanne
Peters, Janny G. P.
Sagar, Seil
Louisse, Jochem
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
During endotoxemia, the ATP-dependent drug efflux pump P-glycoprotein (Abcb1/P-gp) is upregulated in kidney proximal tubule epithelial cells.
The signaling pathway through which lipopolysaccharide (LPS) or tumor necrosis factor-α (TNF-α) regulates P-gp expression and activity was investigated further in the present study.
Exposure of rat kidney proximal tubule cells to TNF-α alone or TNF-α and LPS increased P-gp gene and protein expression levels and efflux activity, suggesting de novo P-gp synthesis.
Upon exposure to TNF-α in combination with LPS, P-gp activity in renal proximal tubule cells is increased under influence of nitric oxide (NO) produced by inducible NO synthase.
Upon exposure to TNF-α alone, P-gp upregulation seems to involve TLR4 activation and nuclear factor kappaB (NF-κB) translocation, a pathway that is likely independent of NO.
These findings indicate that at least two pathways regulate P-gp expression in the kidney during endotoxemia.
American Psychological Association (APA)
Heemskerk, Suzanne& Peters, Janny G. P.& Louisse, Jochem& Sagar, Seil& Russel, Frans G. M.& Masereeuw, Rosalinde. 2010. Regulation of P-Glycoprotein in Renal Proximal Tubule Epithelial Cells by LPS and TNF-α. BioMed Research International،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-988959
Modern Language Association (MLA)
Heemskerk, Suzanne…[et al.]. Regulation of P-Glycoprotein in Renal Proximal Tubule Epithelial Cells by LPS and TNF-α. BioMed Research International No. 2010 (Dec. 2010), pp.1-10.
https://search.emarefa.net/detail/BIM-988959
American Medical Association (AMA)
Heemskerk, Suzanne& Peters, Janny G. P.& Louisse, Jochem& Sagar, Seil& Russel, Frans G. M.& Masereeuw, Rosalinde. Regulation of P-Glycoprotein in Renal Proximal Tubule Epithelial Cells by LPS and TNF-α. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-988959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988959