Mathematical Modeling: Bridging the Gap between Concept and Realization in Synthetic Biology
Joint Authors
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-18
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Mathematical modeling plays an important and often indispensable role in synthetic biology because it serves as a crucial link between the concept and realization of a biological circuit.
We review mathematical modeling concepts and methodologies as relevant to synthetic biology, including assumptions that underlie a model, types of modeling frameworks (deterministic and stochastic), and the importance of parameter estimation and optimization in modeling.
Additionally we expound mathematical techniques used to analyze a model such as sensitivity analysis and bifurcation analysis, which enable the identification of the conditions that cause a synthetic circuit to behave in a desired manner.
We also discuss the role of modeling in phenotype analysis such as metabolic and transcription network analysis and point out some available modeling standards and software.
Following this, we present three case studies—a metabolic oscillator, a synthetic counter, and a bottom-up gene regulatory network—which have incorporated mathematical modeling as a central component of synthetic circuit design.
American Psychological Association (APA)
Zheng, Yuting& Sriram, Ganesh. 2010. Mathematical Modeling: Bridging the Gap between Concept and Realization in Synthetic Biology. BioMed Research International،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-988972
Modern Language Association (MLA)
Zheng, Yuting& Sriram, Ganesh. Mathematical Modeling: Bridging the Gap between Concept and Realization in Synthetic Biology. BioMed Research International No. 2010 (Dec. 2010), pp.1-16.
https://search.emarefa.net/detail/BIM-988972
American Medical Association (AMA)
Zheng, Yuting& Sriram, Ganesh. Mathematical Modeling: Bridging the Gap between Concept and Realization in Synthetic Biology. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-988972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988972