Analysis of Horse Myostatin Gene and Identification of Single Nucleotide Polymorphisms in Breeds of Different Morphological Types
Joint Authors
Fontanesi, Luca
Dall'Olio, Stefania
Falaschini, Adalberto
Minieri, Laura
Tassinari, Marco
Nanni Costa, Leonardo
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Myostatin (MSTN) is a negative modulator of muscle mass.
We characterized the horse (Equus caballus) MSTN gene and identified and analysed single nucleotide polymorphisms (SNPs) in breeds of different morphological types.
Sequencing of coding, untranslated, intronic, and regulatory regions of MSTN gene in 12 horses from 10 breeds revealed seven SNPs: two in the promoter, four in intron 1, and one in intron 2.
The SNPs of the promoter (GQ183900:g.26T>C and GQ183900:g.156T>C, the latter located within a conserved TATA-box like motif) were screened in 396 horses from 16 breeds.
The g.26C and the g.156C alleles presented higher frequency in heavy (brachymorphic type) than in light breeds (dolichomorphic type such as Italian Trotter breed).
The significant difference of allele frequencies for the SNPs at the promoter and analysis of molecular variance (AMOVA) on haplotypes indicates that these polymorphisms could be associated with variability of morphology traits in horse breeds.
American Psychological Association (APA)
Dall'Olio, Stefania& Fontanesi, Luca& Nanni Costa, Leonardo& Tassinari, Marco& Minieri, Laura& Falaschini, Adalberto. 2010. Analysis of Horse Myostatin Gene and Identification of Single Nucleotide Polymorphisms in Breeds of Different Morphological Types. BioMed Research International،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-988980
Modern Language Association (MLA)
Dall'Olio, Stefania…[et al.]. Analysis of Horse Myostatin Gene and Identification of Single Nucleotide Polymorphisms in Breeds of Different Morphological Types. BioMed Research International No. 2010 (Dec. 2010), pp.1-11.
https://search.emarefa.net/detail/BIM-988980
American Medical Association (AMA)
Dall'Olio, Stefania& Fontanesi, Luca& Nanni Costa, Leonardo& Tassinari, Marco& Minieri, Laura& Falaschini, Adalberto. Analysis of Horse Myostatin Gene and Identification of Single Nucleotide Polymorphisms in Breeds of Different Morphological Types. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-988980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988980