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Progesterone Induces Scolex Evagination of the Human Parasite Taenia solium: Evolutionary Implications to the Host-Parasite Relationship
Joint Authors
Hernández-Hernández, Olivia Tania
Morales-Montor, Jorge
Camacho-Arroyo, Ignacio
Escobedo, Galileo
Ostoa-Saloma, Pedro
García-Varela, Martín
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Taenia solium cysticercosis is a health problem in underdeveloped and developed countries.
Sex hormones are involved in cysticercosis prevalence in female and male pigs.
Here, we evaluated the effects of progesterone and its antagonist RU486 on scolex evagination, which is the initial step in the development of the adult worm.
Interestingly, progesterone increased T.
solium scolex evagination and worm growth, in a concentration-independent pattern.
Progesterone effects could be mediated by a novel T.
solium progesterone receptor (TsPR), since RU486 inhibits both scolex evagination and worm development induced by progesterone.
Using RT-PCR and western blot, sequences related to progesterone receptor were detected in the parasite.
A phylogenetic analysis reveals that TsPR is highly related to fish and amphibian progesterone receptors, whereas it has a distant relation with birds and mammals.
Conclusively, progesterone directly acts upon T.
solium cysticerci, possibly through its binding to a progesterone receptor synthesized by the parasite.
American Psychological Association (APA)
Escobedo, Galileo& Camacho-Arroyo, Ignacio& Hernández-Hernández, Olivia Tania& Ostoa-Saloma, Pedro& García-Varela, Martín& Morales-Montor, Jorge. 2009. Progesterone Induces Scolex Evagination of the Human Parasite Taenia solium: Evolutionary Implications to the Host-Parasite Relationship. BioMed Research International،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-989024
Modern Language Association (MLA)
Escobedo, Galileo…[et al.]. Progesterone Induces Scolex Evagination of the Human Parasite Taenia solium: Evolutionary Implications to the Host-Parasite Relationship. BioMed Research International No. 2010 (Dec. 2010), pp.1-10.
https://search.emarefa.net/detail/BIM-989024
American Medical Association (AMA)
Escobedo, Galileo& Camacho-Arroyo, Ignacio& Hernández-Hernández, Olivia Tania& Ostoa-Saloma, Pedro& García-Varela, Martín& Morales-Montor, Jorge. Progesterone Induces Scolex Evagination of the Human Parasite Taenia solium: Evolutionary Implications to the Host-Parasite Relationship. BioMed Research International. 2009. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-989024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989024