A Pivotal Role for Interleukin-27 in CD8+ T Cell Functions and Generation of Cytotoxic T Lymphocytes
Joint Authors
Mizoguchi, Izuru
Xu, Mingli
Okumura, Masae
Mizuguchi, Junichiro
Yoshimoto, Takayuki
Matsui, Masanori
Morishima, Noriko
Shimizu, Motomu
Chiba, Yukino
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cytotoxic T lymphocytes (CTLs) play a critical role in the control of various cancers and infections, and therefore the molecular mechanisms of CTL generation are a critical issue in designing antitumor immunotherapy and vaccines which augment the development of functional and long-lasting memory CTLs.
Interleukin (IL)-27, a member of the IL-6/IL-12 heterodimeric cytokine family, acts on naive CD4+ T cells and plays pivotal roles as a proinflammatory cytokine to promote the early initiation of type-1 helper differentiation and also as an antiinflammatory cytokine to limit the T cell hyperactivity and production of pro-inflammatory cytokines.
Recent studies revealed that IL-27 plays an important role in CD8+ T cells as well.
Therefore, this article reviews current understanding of the role of IL-27 in CD8+ T cell functions and generation of CTLs.
American Psychological Association (APA)
Morishima, Noriko& Mizoguchi, Izuru& Okumura, Masae& Chiba, Yukino& Xu, Mingli& Shimizu, Motomu…[et al.]. 2010. A Pivotal Role for Interleukin-27 in CD8+ T Cell Functions and Generation of Cytotoxic T Lymphocytes. BioMed Research International،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-989031
Modern Language Association (MLA)
Morishima, Noriko…[et al.]. A Pivotal Role for Interleukin-27 in CD8+ T Cell Functions and Generation of Cytotoxic T Lymphocytes. BioMed Research International No. 2010 (Dec. 2010), pp.1-10.
https://search.emarefa.net/detail/BIM-989031
American Medical Association (AMA)
Morishima, Noriko& Mizoguchi, Izuru& Okumura, Masae& Chiba, Yukino& Xu, Mingli& Shimizu, Motomu…[et al.]. A Pivotal Role for Interleukin-27 in CD8+ T Cell Functions and Generation of Cytotoxic T Lymphocytes. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-989031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989031
