![](/images/graphics-bg.png)
Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice
Joint Authors
Chang, Chen-Kuei
Tai, Po-An
Lin, Mao- Tsun
Niu, Ko-Chi
Lin, Jia-Wei
Chiu, Wen-Ta
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aims of the present paper were to ascertain whether the heat-induced ischemia and oxidative damage to the hypothalamus and lethality in mice could be ameliorated by hyperbaric oxygen therapy.
When normobaric air-treated mice underwent heat treatment, the fractional survival and core temperature at 4 hours after heat stress were found to be 0 of 12 and 34∘C±0.3∘C, respectively.
In hyperbaric oxygen-treated mice, when exposed to the same treatment, both fractional survival and core temperature values were significantly increased to new values of 12/12 and 37.3∘C±0.3∘C, respectively.
Compared to normobaric air-treated heatstroke mice, hyperbaric oxygen-treated mice displayed lower hypothalamic values of cellular ischemia and damage markers, prooxidant enzymes, proinflammatory cytokines, inducible nitric oxide synthase-dependent nitric oxide, and neuronal damage score.
The data indicate that hyperbaric oxygen may improve outcomes of heatstroke by normalization of hypothalamic and thermoregulatory function in mice.
American Psychological Association (APA)
Tai, Po-An& Chang, Chen-Kuei& Niu, Ko-Chi& Lin, Mao- Tsun& Chiu, Wen-Ta& Lin, Jia-Wei. 2010. Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice. BioMed Research International،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989034
Modern Language Association (MLA)
Tai, Po-An…[et al.]. Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice. BioMed Research International No. 2010 (Dec. 2010), pp.1-11.
https://search.emarefa.net/detail/BIM-989034
American Medical Association (AMA)
Tai, Po-An& Chang, Chen-Kuei& Niu, Ko-Chi& Lin, Mao- Tsun& Chiu, Wen-Ta& Lin, Jia-Wei. Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989034