Biomarkers for Lupus Nephritis: A Critical Appraisal
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Kidney disease is one of the most serious manifestations of systemic lupus erythematosus (SLE).
Despite the improvement in the medical care of SLE in the past two decades, the prognosis of lupus nephritis remains unsatisfactory.
Besides exploring more effective but less toxic treatment modalities that will further improve the remission rate, early detection and treatment of renal activity may spare patients from intensive immunosuppressive therapies and reduce renal damage.
Conventional clinical parameters such as creatinine clearance, proteinuria, urine sediments, anti-dsDNA, and complement levels are not sensitive or specific enough for detecting ongoing disease activity in the lupus kidneys and early relapse of nephritis.
Thus, novel biomarkers are necessary to enhance the diagnostic accuracy and sensitivity of lupus renal disease, prognostic stratification, monitoring of treatment response, and detection of early renal flares.
This paper reviews promising biomarkers that have recently been evaluated in longitudinal studies of lupus nephritis.
American Psychological Association (APA)
Mok, Chi Chiu. 2010. Biomarkers for Lupus Nephritis: A Critical Appraisal. BioMed Research International،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989046
Modern Language Association (MLA)
Mok, Chi Chiu. Biomarkers for Lupus Nephritis: A Critical Appraisal. BioMed Research International No. 2010 (Dec. 2010), pp.1-11.
https://search.emarefa.net/detail/BIM-989046
American Medical Association (AMA)
Mok, Chi Chiu. Biomarkers for Lupus Nephritis: A Critical Appraisal. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989046