Thrombin Inhibitors from Different Animals
Joint Authors
Tanaka, Aparecida Sadae
de Morais-Zani, Karen
Torquato, Ricardo José
Tanaka-Azevedo, Anita Mitico
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Venous and arterial thromboembolic diseases are still the most frequent causes of death and disability in high-income countries.
Clinical anticoagulants are inhibitors of enzymes involved in the coagulation pathway, such as thrombin and factor Xa.
Thrombin is a key enzyme of blood coagulation system, activating the platelets, converting the fibrinogen to the fibrin net, and amplifying its self-generation by the activation of factors V, VIII, and XI.
Thrombin has long been a target for the development of oral anticoagulants.
Furthermore, selective inhibitors of thrombin represent a new class of antithrombotic agents.
For these reasons, a number of specific thrombin inhibitors are under evaluation for possible use as antithrombotic drugs.
This paper summarizes old and new interests of specific thrombin inhibitors described in different animals.
American Psychological Association (APA)
Tanaka-Azevedo, Anita Mitico& de Morais-Zani, Karen& Torquato, Ricardo José& Tanaka, Aparecida Sadae. 2010. Thrombin Inhibitors from Different Animals. BioMed Research International،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989048
Modern Language Association (MLA)
Tanaka-Azevedo, Anita Mitico…[et al.]. Thrombin Inhibitors from Different Animals. BioMed Research International No. 2010 (Dec. 2010), pp.1-9.
https://search.emarefa.net/detail/BIM-989048
American Medical Association (AMA)
Tanaka-Azevedo, Anita Mitico& de Morais-Zani, Karen& Torquato, Ricardo José& Tanaka, Aparecida Sadae. Thrombin Inhibitors from Different Animals. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989048