A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment
Joint Authors
Nishino, Taiko
Shimo, Hanae
Suematsu, Makoto
Tomita, Masaru
Yachie-Kinoshita, Ayako
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The human red blood cell (RBC) has long been used for modeling of complex biological networks, for elucidation of a wide variety of dynamic phenomena, and for understanding the fundamental topology of metabolic pathways.
Here, we introduce our recent work on an RBC metabolic model using the E-Cell Simulation Environment.
The model is sufficiently detailed to predict the temporal hypoxic response of each metabolite and, at the same time, successfully integrates modulation of metabolism and of the oxygen transporting capacity of hemoglobin.
The model includes the mechanisms of RBC maintenance as a single cell system and the functioning of RBCs as components of a higher order system.
Modeling of RBC metabolism is now approaching a fully mature stage of realistic predictions at the molecular level and will be useful for predicting conditions in biotechnological applications such as long-term cold storage of RBCs.
American Psychological Association (APA)
Yachie-Kinoshita, Ayako& Nishino, Taiko& Shimo, Hanae& Suematsu, Makoto& Tomita, Masaru. 2010. A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment. BioMed Research International،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-989050
Modern Language Association (MLA)
Yachie-Kinoshita, Ayako…[et al.]. A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment. BioMed Research International No. 2010 (Dec. 2010), pp.1-14.
https://search.emarefa.net/detail/BIM-989050
American Medical Association (AMA)
Yachie-Kinoshita, Ayako& Nishino, Taiko& Shimo, Hanae& Suematsu, Makoto& Tomita, Masaru. A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-989050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989050