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Combination of Intensive Chemotherapy and Anticancer Vaccines in the Treatment of Human Malignancies: The Hematological Experience
Joint Authors
Liseth, Knut
Ersvaer, Elisabeth
Bruserud, Øystein
Hervig, Tor
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
In vitro studies have demonstrated that cancer-specific T cell cytotoxicity can be induced both ex vivo and in vivo, but this therapeutic strategy should probably be used as an integrated part of a cancer treatment regimen.
Initial chemotherapy should be administered to reduce the cancer cell burden and disease-induced immune defects.
This could be followed by autologous stem cell transplantation that is a safe procedure including both high-dose disease-directed chemotherapy and the possibility for ex vivo enrichment of the immunocompetent graft cells.
The most intensive conventional chemotherapy and stem cell transplantation are used especially in the treatment of aggressive hematologic malignancies; both strategies induce T cell defects that may last for several months but cancer-specific T cell reactivity is maintained after both procedures.
Enhancement of anticancer T cell cytotoxicity is possible but posttransplant vaccination therapy should probably be combined with optimalisation of immunoregulatory networks.
Such combinatory regimens should be suitable for patients with aggressive hematological malignancies and probably also for other cancer patients.
American Psychological Association (APA)
Liseth, Knut& Ersvaer, Elisabeth& Hervig, Tor& Bruserud, Øystein. 2010. Combination of Intensive Chemotherapy and Anticancer Vaccines in the Treatment of Human Malignancies: The Hematological Experience. BioMed Research International،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-989069
Modern Language Association (MLA)
Liseth, Knut…[et al.]. Combination of Intensive Chemotherapy and Anticancer Vaccines in the Treatment of Human Malignancies: The Hematological Experience. BioMed Research International No. 2010 (Dec. 2010), pp.1-15.
https://search.emarefa.net/detail/BIM-989069
American Medical Association (AMA)
Liseth, Knut& Ersvaer, Elisabeth& Hervig, Tor& Bruserud, Øystein. Combination of Intensive Chemotherapy and Anticancer Vaccines in the Treatment of Human Malignancies: The Hematological Experience. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-989069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989069