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Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice
Joint Authors
Labeit, Siegfried
Witt, Christian C.
Kohl, Christine H.
Granzier, Henk L. M.
Jung, Jeong
Labeit, Dittmar
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
MuRF1 is a member of the TRIM/RBCC superfamily, a gene family that encompasses a large variety of proteins, all sharing the conserved TRIM (Tripartite Motive) sequential array of RING, B-box, and coiled-coil domains.
Within this family, MuRF1(also named TRIM63) is a specialized member that contributes to the development of muscle atrophy and sarcopenia.
Here we studied MuRF1's role in muscle atrophy during muscle unloading induced by hindlimb suspension.
Consistent with previous studies, we found that MuRF1 inactivation leads to an attenuated muscle atrophy response.
The amount of protection was higher as compared to the denervation model, and within the 10 day-suspension period the soleus muscle was spared from atrophy in MuRF1-KO mice.
Contractility studies on hindlimb suspended muscle tissues suggested that MuRF1's functions extend beyond muscle trophicity and implicate MuRF1 in muscle fatigue and MLC phosphorylation control: soleus muscle from MuRF1-KO mice fatigued significantly faster and in addition showed a reduced posttetanic twitch potentiation.
Thus the present work further established the role of MuRF1 in muscle atrophy and for the first time shows that MuRF1 plays a role in muscle fatigue and twitch potentiation.
American Psychological Association (APA)
Labeit, Siegfried& Kohl, Christine H.& Witt, Christian C.& Labeit, Dittmar& Jung, Jeong& Granzier, Henk L. M.. 2010. Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice. BioMed Research International،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989071
Modern Language Association (MLA)
Labeit, Siegfried…[et al.]. Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice. BioMed Research International No. 2010 (Dec. 2010), pp.1-9.
https://search.emarefa.net/detail/BIM-989071
American Medical Association (AMA)
Labeit, Siegfried& Kohl, Christine H.& Witt, Christian C.& Labeit, Dittmar& Jung, Jeong& Granzier, Henk L. M.. Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989071