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Phenotypic Transition of the Collecting Duct Epithelium in Congenital Urinary Tract Obstruction
Joint Authors
Trnka, Peter
Ivanova, Larissa
Matsell, Douglas G.
Hiatt, Michael J.
Tarantal, Alice F.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Epithelial-mesenchymal transition (EMT) has emerged in recent years as an important process in the development of organ fibrosis in many human diseases.
Our previous experience in a nonhuman primate model of obstructive nephropathy suggested that EMT of collecting duct epithelium contributes to the development of interstitial fibrosis.
In this study we demonstrate for the first time in humans that obstructed fetal collecting duct epithelium undergoes transition to mesenchymal phenotype, characterized by decreased expression of epithelial markers, de novo expression of mesenchymal markers with subsequent loss of cell-cell interaction, disruption of the basement membrane, and increased deposition of extracellular matrix into the expanded interstitium of the obstructed kidney.
The results of this study therefore support the previous findings from animal studies and suggest that EMT of the collecting duct epithelium might contribute to the development of interstitial fibrosis in human fetal obstructive nephropathy.
American Psychological Association (APA)
Trnka, Peter& Hiatt, Michael J.& Ivanova, Larissa& Tarantal, Alice F.& Matsell, Douglas G.. 2009. Phenotypic Transition of the Collecting Duct Epithelium in Congenital Urinary Tract Obstruction. BioMed Research International،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989072
Modern Language Association (MLA)
Trnka, Peter…[et al.]. Phenotypic Transition of the Collecting Duct Epithelium in Congenital Urinary Tract Obstruction. BioMed Research International No. 2010 (Dec. 2010), pp.1-9.
https://search.emarefa.net/detail/BIM-989072
American Medical Association (AMA)
Trnka, Peter& Hiatt, Michael J.& Ivanova, Larissa& Tarantal, Alice F.& Matsell, Douglas G.. Phenotypic Transition of the Collecting Duct Epithelium in Congenital Urinary Tract Obstruction. BioMed Research International. 2009. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989072