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Neighborhood Rough Set Reduction-Based Gene Selection and Prioritization for Gene Expression Profile Analysis and Molecular Cancer Classification
Joint Authors
Li, Xue-Ling
Wang, Shu-Lin
Hou, Mei-Ling
Lei, Ying-Ke
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Selection of reliable cancer biomarkers is crucial for gene expression profile-based precise diagnosis of cancer type and successful treatment.
However, current studies are confronted with overfitting and dimensionality curse in tumor classification and false positives in the identification of cancer biomarkers.
Here, we developed a novel gene-ranking method based on neighborhood rough set reduction for molecular cancer classification based on gene expression profile.
Comparison with other methods such as PAM, ClaNC, Kruskal-Wallis rank sum test, and Relief-F, our method shows that only few top-ranked genes could achieve higher tumor classification accuracy.
Moreover, although the selected genes are not typical of known oncogenes, they are found to play a crucial role in the occurrence of tumor through searching the scientific literature and analyzing protein interaction partners, which may be used as candidate cancer biomarkers.
American Psychological Association (APA)
Hou, Mei-Ling& Wang, Shu-Lin& Li, Xue-Ling& Lei, Ying-Ke. 2010. Neighborhood Rough Set Reduction-Based Gene Selection and Prioritization for Gene Expression Profile Analysis and Molecular Cancer Classification. BioMed Research International،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989092
Modern Language Association (MLA)
Hou, Mei-Ling…[et al.]. Neighborhood Rough Set Reduction-Based Gene Selection and Prioritization for Gene Expression Profile Analysis and Molecular Cancer Classification. BioMed Research International No. 2010 (Dec. 2010), pp.1-12.
https://search.emarefa.net/detail/BIM-989092
American Medical Association (AMA)
Hou, Mei-Ling& Wang, Shu-Lin& Li, Xue-Ling& Lei, Ying-Ke. Neighborhood Rough Set Reduction-Based Gene Selection and Prioritization for Gene Expression Profile Analysis and Molecular Cancer Classification. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989092