Toll-Like Receptor Initiated Host Defense againstToxoplasma gondii

Abstract EN

Toxoplasma gondii is an intracellular pathogen notable for its ability to establish a stable host-parasite relationship amongst a wide range of host species and in a large percentage of the human population.

Toll-like receptor signaling through MyD88 is a critical pathway in initiating defense against this opportunistic protozoan and may also be a mediator of pathology during immune dysfunction.

Other MyD88 independent signaling pathways are also involved in the host-parasite interaction.

These responses can be triggered by the parasite itself, but interactions with the intestinal microbiota add additional complexity during enteric infection.