Biological Role of Dystroglycan in Schwann Cell Function and Its Implications in Peripheral Nervous System Diseases
Joint Authors
Masaki, Toshihiro
Matsumura, Kiichiro
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-25
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC) that links extracellular matrix with cytoskeleton, expressed in a variety of fetal and adult tissues.
Dystroglycan plays diverse roles in development and homeostasis including basement membrane formation, epithelial morphogenesis, membrane stability, cell polarization, and cell migration.
In this paper, we will focus on biological role of dystroglycan in Schwann cell function, especially myelination.
First, we review the molecular architecture of DGC in Schwann cell abaxonal membrane.
Then, we will review the loss-of-function studies using targeted mutagenesis, which have revealed biological functions of each component of DGC in Schwann cells.
Based on these findings, roles of dystroglycan in Schwann cell function, in myelination in particular, and its implications in diseases will be discussed in detail.
Finally, in view of the fact that understanding the role of dystroglycan in Schwann cells is just beginning, future perspectives will be discussed.
American Psychological Association (APA)
Masaki, Toshihiro& Matsumura, Kiichiro. 2010. Biological Role of Dystroglycan in Schwann Cell Function and Its Implications in Peripheral Nervous System Diseases. BioMed Research International،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-989101
Modern Language Association (MLA)
Masaki, Toshihiro& Matsumura, Kiichiro. Biological Role of Dystroglycan in Schwann Cell Function and Its Implications in Peripheral Nervous System Diseases. BioMed Research International No. 2010 (Dec. 2010), pp.1-17.
https://search.emarefa.net/detail/BIM-989101
American Medical Association (AMA)
Masaki, Toshihiro& Matsumura, Kiichiro. Biological Role of Dystroglycan in Schwann Cell Function and Its Implications in Peripheral Nervous System Diseases. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-989101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989101