The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity
Joint Authors
Tsokos, George C.
Lieberman, Linda A.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity.
Transcription factors regulating IL-2 production behave aberrantly in SLE T cells.
In addition to IL-2 dysregulation, other IL-2 family members (IL-15 and IL-21) are abnormally expressed in SLE.
Decreased IL-2 production in SLE patients leads to many immune defects such as decreased Treg production, decreased activation-induced cell death (AICD), and decreased cytotoxicity.
IL-2 deficiency results in systemic dysregulation of host immune responses in patients suffering from SLE disease.
American Psychological Association (APA)
Lieberman, Linda A.& Tsokos, George C.. 2010. The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity. BioMed Research International،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-989102
Modern Language Association (MLA)
Lieberman, Linda A.& Tsokos, George C.. The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity. BioMed Research International No. 2010 (Dec. 2010), pp.1-6.
https://search.emarefa.net/detail/BIM-989102
American Medical Association (AMA)
Lieberman, Linda A.& Tsokos, George C.. The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-989102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989102
