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Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells
Joint Authors
Hara, Eiichi
Homma, Sadamu
Koido, Shigeo
Namiki, Yoshihisa
Ohkusa, Toshifumi
Gong, Jianlin
Tajiri, Hisao
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass.
Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses.
Thus, DCs-based vaccination represents a potentially powerful strategy for induction of antigen-specific CTLs.
Fusions of DCs and whole tumor cells represent an alternative approach to deliver, process, and subsequently present a broad spectrum of antigens, including those known and unidentified, in the context of costimulatory molecules.
Once DCs/tumor fusions have been infused back into patient, they migrate to secondary lymphoid organs, where the generation of antigen-specific polyclonal CTL responses occurs.
We will discuss perspectives for future development of DCs/tumor fusions for CTL induction.
American Psychological Association (APA)
Koido, Shigeo& Homma, Sadamu& Hara, Eiichi& Namiki, Yoshihisa& Ohkusa, Toshifumi& Gong, Jianlin…[et al.]. 2010. Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells. BioMed Research International،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989106
Modern Language Association (MLA)
Koido, Shigeo…[et al.]. Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells. BioMed Research International No. 2010 (Dec. 2010), pp.1-12.
https://search.emarefa.net/detail/BIM-989106
American Medical Association (AMA)
Koido, Shigeo& Homma, Sadamu& Hara, Eiichi& Namiki, Yoshihisa& Ohkusa, Toshifumi& Gong, Jianlin…[et al.]. Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989106