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Which Metabolic Pathways Generate and Characterize the Flux Space? A Comparison among Elementary Modes, Extreme Pathways and Minimal Generators
Joint Authors
Llaneras, Francisco
Picó, Jesús
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Important efforts are being done to systematically identify the relevant pathways in a metabolic network.
Unsurprisingly, there is not a unique set of network-based pathways to be tagged as relevant, and at least four related concepts have been proposed: extreme currents, elementary modes, extreme pathways, and minimal generators.
Basically, there are two properties that these sets of pathways can hold: they can generate the flux space—if every feasible flux distribution can be represented as a nonnegative combination of flux through them—or they can comprise all the nondecomposable pathways in the network.
The four concepts fulfill the first property, but only the elementary modes fulfill the second one.
This subtle difference has been a source of errors and misunderstandings.
This paper attempts to clarify the intricate relationship between the network-based pathways performing a comparison among them.
American Psychological Association (APA)
Llaneras, Francisco& Picó, Jesús. 2010. Which Metabolic Pathways Generate and Characterize the Flux Space? A Comparison among Elementary Modes, Extreme Pathways and Minimal Generators. BioMed Research International،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-989109
Modern Language Association (MLA)
Llaneras, Francisco& Picó, Jesús. Which Metabolic Pathways Generate and Characterize the Flux Space? A Comparison among Elementary Modes, Extreme Pathways and Minimal Generators. BioMed Research International No. 2010 (Dec. 2010), pp.1-13.
https://search.emarefa.net/detail/BIM-989109
American Medical Association (AMA)
Llaneras, Francisco& Picó, Jesús. Which Metabolic Pathways Generate and Characterize the Flux Space? A Comparison among Elementary Modes, Extreme Pathways and Minimal Generators. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-989109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989109