Induction of Specific CD8+ T Cells against Intracellular Bacteria by CD8+ T-Cell-Oriented Immunization Approaches
Joint Authors
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
For protection against intracellular bacteria such as Mycobacterium tuberculosis and Listeria monocytogenes, the cellular arm of adaptive immunity is necessary.
A variety of immunization methods have been evaluated and are reported to induce specific CD8+ T cells against intracellular bacterial infection.
Modified BCG vaccines have been examined to enhance CD8+ T-cell responses.
Naked DNA vaccination is a promising strategy to induce CD8+ T cells.
In addition to this strategy, live attenuated intracellular bacteria such as Shigella, Salmonella, and Listeria have been utilized as carriers of DNA vaccines in animal models.
Vaccination with dendritic cells pulsed with antigenic peptides or the cells introduced antigen genes by virus vectors such as retroviruses is also a powerful strategy.
Furthermore, vaccination with recombinant lentivirus has been attempted to induce specific CD8+ T cells.
Combinations of these strategies (prime-boost immunization) have been studied for the efficient induction of intracellular bacteria-specific CD8+ T cells.
American Psychological Association (APA)
Nagata, Toshi& Koide, Yukio. 2010. Induction of Specific CD8+ T Cells against Intracellular Bacteria by CD8+ T-Cell-Oriented Immunization Approaches. BioMed Research International،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989114
Modern Language Association (MLA)
Nagata, Toshi& Koide, Yukio. Induction of Specific CD8+ T Cells against Intracellular Bacteria by CD8+ T-Cell-Oriented Immunization Approaches. BioMed Research International No. 2010 (Dec. 2010), pp.1-11.
https://search.emarefa.net/detail/BIM-989114
American Medical Association (AMA)
Nagata, Toshi& Koide, Yukio. Induction of Specific CD8+ T Cells against Intracellular Bacteria by CD8+ T-Cell-Oriented Immunization Approaches. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989114