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Reduction of Foxp3+ Cells by Depletion with the PC61 mAb Induces Mortality in Resistant BALBc Mice Infected with Toxoplasma gondii
Joint Authors
Fernández, Jacquelina
Vieyra, Pablo
Saavedra, Rafael
Tenorio, Eda Patricia
Olguín, Jonadab Efraín
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Regulatory T cells (Tregs) are CD4+Foxp3+ cells that modulate autoimmune responses.
Tregs have been shown to be also involved during the immune response against infectious agents.
The aim of this work is to study the role of Tregs during the infection with the intracellular protozoan Toxoplasma gondii.
Resistant BALB/c mice were injected with 200 μg of anti-CD25 mAb (clone PC61) and 2 days later they were infected with 20 cysts of the ME49 strain of T.
gondii.
We observed that depleted mice showed 50–60% mortality during the acute infection.
When FACS analysis was carried out, we observed that although injection of PC61 mAb eliminated 50% of Tregs, infected-depleted mice showed a similar percentage of CD25+Foxp3− (activated T cells, Tact) to those observed in infected nondepleted animals, demonstrating that in our depletion/infection system, injection of PC61 mAb did not hamper T cell activation while percentage of Tregs was reduced by 75% 10 days post infection.
We concluded that Tregs are essential during protection in the acute phase of T.
gondii infection.
American Psychological Association (APA)
Tenorio, Eda Patricia& Olguín, Jonadab Efraín& Fernández, Jacquelina& Vieyra, Pablo& Saavedra, Rafael. 2009. Reduction of Foxp3+ Cells by Depletion with the PC61 mAb Induces Mortality in Resistant BALBc Mice Infected with Toxoplasma gondii. BioMed Research International،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989118
Modern Language Association (MLA)
Tenorio, Eda Patricia…[et al.]. Reduction of Foxp3+ Cells by Depletion with the PC61 mAb Induces Mortality in Resistant BALBc Mice Infected with Toxoplasma gondii. BioMed Research International No. 2010 (Dec. 2010), pp.1-9.
https://search.emarefa.net/detail/BIM-989118
American Medical Association (AMA)
Tenorio, Eda Patricia& Olguín, Jonadab Efraín& Fernández, Jacquelina& Vieyra, Pablo& Saavedra, Rafael. Reduction of Foxp3+ Cells by Depletion with the PC61 mAb Induces Mortality in Resistant BALBc Mice Infected with Toxoplasma gondii. BioMed Research International. 2009. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989118