Hydrogen Peroxide Toxicity Induces Ras Signaling in Human Neuroblastoma SH-SY5Y Cultured Cells
Joint Authors
Govitrapong, Piyarat
Chetsawang, Jirapa
Chetsawang, Banthit
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
It has been reported that overproduction of reactive oxygen species occurs after brain injury and mediates neuronal cells degeneration.
In the present study, we examined the role of Ras signaling on hydrogen peroxide-induced neuronal cells degeneration in dopaminergic neuroblastoma SH-SY5Y cells.
Hydrogen peroxide significantly reduced cell viability in SH-SY5Y cultured cells.
An inhibitor of the enzyme that catalyzes the farnesylation of Ras proteins, FTI-277, and a competitive inhibitor of GTP-binding proteins, GDP-beta-S significantly decreased hydrogen peroxide-induced reduction in cell viability in SH-SY5Y cultured cells.
The results of this study might indicate that a Ras-dependent signaling pathway plays a role in hydrogen peroxide-induced toxicity in neuronal cells.
American Psychological Association (APA)
Chetsawang, Jirapa& Govitrapong, Piyarat& Chetsawang, Banthit. 2010. Hydrogen Peroxide Toxicity Induces Ras Signaling in Human Neuroblastoma SH-SY5Y Cultured Cells. BioMed Research International،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-989127
Modern Language Association (MLA)
Chetsawang, Jirapa…[et al.]. Hydrogen Peroxide Toxicity Induces Ras Signaling in Human Neuroblastoma SH-SY5Y Cultured Cells. BioMed Research International No. 2010 (Dec. 2010), pp.1-4.
https://search.emarefa.net/detail/BIM-989127
American Medical Association (AMA)
Chetsawang, Jirapa& Govitrapong, Piyarat& Chetsawang, Banthit. Hydrogen Peroxide Toxicity Induces Ras Signaling in Human Neuroblastoma SH-SY5Y Cultured Cells. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-989127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989127