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Matrix Metalloproteinase-2 Promoter Genotype as a Marker ofCutaneous T-Cell Lymphoma Early Stage
Joint Authors
Nečas, Miroslav
Vasku, Julie Bienertova
Vasku, Vladimir
Vasku, Anna
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of the study was to investigate the DNA polymorphic genotype in MMP-2 promoter gene as a potential candidate region for the development of the cutaneous T-cell lymphoma (CTCL) and/or its progression.
A total of 89 Czech patients with CTCL (including 23 patients with large plaque parapsoriasis) were compared to 198 controls of similar age and sex distribution, without personal or family history of chronic skin diseases and without personal history of malignancy.
The three selected polymorphisms in the promoter of MMP-2 gene (−1575G/A, −1306C/T, and −790T/G) were determined using the PCR-based methodology with RFLP.
In our cohort, the associated GGCCTT MMP-2 promoter genotype was highly significantly more frequent in CTCL-Ia stage patients compared to patients with parapsoriasis, the tests having high sensitivity and specificity (78%, 83%, resp.).
To conclude, use of associated MMP-2 promoter genotype as a DNA marker might make it possible to distinguish between the patients with parapsoriasis and those with CTCL stage Ia, which could substantially improve possibilities of clinical diagnostics, therapy design, and prognosis of this serious condition in the early stages.
American Psychological Association (APA)
Vasku, Anna& Vasku, Julie Bienertova& Nečas, Miroslav& Vasku, Vladimir. 2010. Matrix Metalloproteinase-2 Promoter Genotype as a Marker ofCutaneous T-Cell Lymphoma Early Stage. BioMed Research International،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-989129
Modern Language Association (MLA)
Vasku, Anna…[et al.]. Matrix Metalloproteinase-2 Promoter Genotype as a Marker ofCutaneous T-Cell Lymphoma Early Stage. BioMed Research International No. 2010 (Dec. 2010), pp.1-5.
https://search.emarefa.net/detail/BIM-989129
American Medical Association (AMA)
Vasku, Anna& Vasku, Julie Bienertova& Nečas, Miroslav& Vasku, Vladimir. Matrix Metalloproteinase-2 Promoter Genotype as a Marker ofCutaneous T-Cell Lymphoma Early Stage. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-989129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989129