IL-10 and TNFα Genotypes in SLE
Joint Authors
Gutiérrez, Carmen
López, Patricia
Suárez, Ana
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The production of two regulators of the inflammatory response, interleukin 10 (IL-10) and tumor necrosis factor α (TNFα), has been found to be deeply deregulated in SLE patients, suggesting that these cytokines may be involved in the pathogenesis of the disease.
Genetic polymorphisms at the promoter regions of IL-10 and TNFα genes have been associated with different constitutive and induced cytokine production.
Given that individual steady-state levels of these molecules may deviate an initial immune response towards different forms of lymphocyte activation, functional genetic variants in their promoters could influence the development of SLE.
The present review summarizes the information previously reported about the involvement of IL-10 and TNFα genetic variants on SLE appearance, clinical phenotype, and outcome.
We show that, in spite of the heterogeneity of the populations studied, the existing knowledge points towards a relevant role of IL-10 and TNFα genotypes in SLE.
American Psychological Association (APA)
López, Patricia& Gutiérrez, Carmen& Suárez, Ana. 2010. IL-10 and TNFα Genotypes in SLE. BioMed Research International،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989141
Modern Language Association (MLA)
López, Patricia…[et al.]. IL-10 and TNFα Genotypes in SLE. BioMed Research International No. 2010 (Dec. 2010), pp.1-11.
https://search.emarefa.net/detail/BIM-989141
American Medical Association (AMA)
López, Patricia& Gutiérrez, Carmen& Suárez, Ana. IL-10 and TNFα Genotypes in SLE. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989141