Dynamic Strength of Titin's Z-Disk End
Joint Authors
Kollár, Veronika
Grama, László
Kellermayer, Miklós S. Z.
Szatmári, Dávid
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Titin is a giant filamentous protein traversing the half sarcomere of striated muscle with putative functions as diverse as providing structural template, generating elastic response, and sensing and relaying mechanical information.
The Z-disk region of titin, which corresponds to the N-terminal end of the molecule, has been thought to be a hot spot for mechanosensing while also serving as anchorage for its sarcomeric attachment.
Understanding the mechanics of titin's Z-disk region, particularly under the effect of binding proteins, is of great interest.
Here we briefly review recent findings on the structure, molecular associations, and mechanics of titin's Z-disk region.
In addition, we report experimental results on the dynamic strength of titin's Z1Z2 domains measured by nanomechanical manipulation of the chemical dimer of a recombinant protein fragment.
American Psychological Association (APA)
Kollár, Veronika& Szatmári, Dávid& Grama, László& Kellermayer, Miklós S. Z.. 2010. Dynamic Strength of Titin's Z-Disk End. BioMed Research International،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989142
Modern Language Association (MLA)
Kollár, Veronika…[et al.]. Dynamic Strength of Titin's Z-Disk End. BioMed Research International No. 2010 (Dec. 2010), pp.1-8.
https://search.emarefa.net/detail/BIM-989142
American Medical Association (AMA)
Kollár, Veronika& Szatmári, Dávid& Grama, László& Kellermayer, Miklós S. Z.. Dynamic Strength of Titin's Z-Disk End. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989142