Expressions of Neuregulin 1β and ErbB4 in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by Chronic MK-801 Administration
Joint Authors
Wang, Xiao-Dong
Feng, Yu
Yang, Yang
Su, Yun'ai
Li, Ji-Tao
Guo, Chun-Mei
Si, Tian-Mei
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recent human genetic studies and postmortem brain examinations of schizophrenia patients strongly indicate that dysregulation of NRG1 and ErbB4 may be important pathogenic factors of schizophrenia.
However, this hypothesis has not been validated and fully investigated in animal models of schizophrenia.
In this study we quantitatively examined NRG1 and ErbB4 protein expressions by immunohistochemistry and Western blot in the brain of a rat schizophrenia model induced by chronic administration of MK-801 (a noncompetitive NMDA receptor antagonist).
Our data showed that NRG1β and ErbB4 expressions were significantly increased in the rat prefrontal cortex and hippocampus but in different subregions.
These findings suggest that altered expressions of NRG1 and ErbB4 might be attributed to the schizophrenia.
Further study in the role and mechanism of NRG1 and ErbB4 may lead to better understanding of the pathophysiology for this disorder.
American Psychological Association (APA)
Feng, Yu& Wang, Xiao-Dong& Guo, Chun-Mei& Yang, Yang& Li, Ji-Tao& Su, Yun'ai…[et al.]. 2010. Expressions of Neuregulin 1β and ErbB4 in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by Chronic MK-801 Administration. BioMed Research International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-989160
Modern Language Association (MLA)
Feng, Yu…[et al.]. Expressions of Neuregulin 1β and ErbB4 in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by Chronic MK-801 Administration. BioMed Research International No. 2010 (Dec. 2010), pp.1-7.
https://search.emarefa.net/detail/BIM-989160
American Medical Association (AMA)
Feng, Yu& Wang, Xiao-Dong& Guo, Chun-Mei& Yang, Yang& Li, Ji-Tao& Su, Yun'ai…[et al.]. Expressions of Neuregulin 1β and ErbB4 in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by Chronic MK-801 Administration. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-989160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989160