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Controlling Influenza by Cytotoxic T-Cells: Calling for Help from Destroyers
Joint Authors
Saelens, Xavier
Ibañez, Lorena Itatí
Fiers, Walter
Schotsaert, Michael
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Influenza is a vaccine preventable disease that causes severe illness and excess mortality in humans.
Licensed influenza vaccines induce humoral immunity and protect against strains that antigenically match the major antigenic components of the vaccine, but much less against antigenically diverse influenza strains.
A vaccine that protects against different influenza viruses belonging to the same subtype or even against viruses belonging to more than one subtype would be a major advance in our battle against influenza.
Heterosubtypic immunity could be obtained by cytotoxic T-cell (CTL) responses against conserved influenza virus epitopes.
The molecular mechanisms involved in inducing protective CTL responses are discussed here.
We also focus on CTL vaccine design and point to the importance of immune-related databases and immunoinformatics tools in the quest for new vaccine candidates.
Some techniques for analysis of T-cell responses are also highlighted, as they allow estimation of cellular immune responses induced by vaccine preparations and can provide correlates of protection.
American Psychological Association (APA)
Schotsaert, Michael& Ibañez, Lorena Itatí& Fiers, Walter& Saelens, Xavier. 2010. Controlling Influenza by Cytotoxic T-Cells: Calling for Help from Destroyers. BioMed Research International،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-989163
Modern Language Association (MLA)
Schotsaert, Michael…[et al.]. Controlling Influenza by Cytotoxic T-Cells: Calling for Help from Destroyers. BioMed Research International No. 2010 (Dec. 2010), pp.1-13.
https://search.emarefa.net/detail/BIM-989163
American Medical Association (AMA)
Schotsaert, Michael& Ibañez, Lorena Itatí& Fiers, Walter& Saelens, Xavier. Controlling Influenza by Cytotoxic T-Cells: Calling for Help from Destroyers. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-989163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989163