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Bioinformatics in New Generation Flavivirus Vaccines
Joint Authors
Koraka, Penelope
Martina, Byron E. E.
Osterhaus, Albert D. M. E.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-05
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Flavivirus infections are the most prevalent arthropod-borne infections world wide, often causing severe disease especially among children, the elderly, and the immunocompromised.
In the absence of effective antiviral treatment, prevention through vaccination would greatly reduce morbidity and mortality associated with flavivirus infections.
Despite the success of the empirically developed vaccines against yellow fever virus, Japanese encephalitis virus and tick-borne encephalitis virus, there is an increasing need for a more rational design and development of safe and effective vaccines.
Several bioinformatic tools are available to support such rational vaccine design.
In doing so, several parameters have to be taken into account, such as safety for the target population, overall immunogenicity of the candidate vaccine, and efficacy and longevity of the immune responses triggered.
Examples of how bio-informatics is applied to assist in the rational design and improvements of vaccines, particularly flavivirus vaccines, are presented and discussed.
American Psychological Association (APA)
Koraka, Penelope& Martina, Byron E. E.& Osterhaus, Albert D. M. E.. 2010. Bioinformatics in New Generation Flavivirus Vaccines. BioMed Research International،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-989164
Modern Language Association (MLA)
Koraka, Penelope…[et al.]. Bioinformatics in New Generation Flavivirus Vaccines. BioMed Research International No. 2010 (Dec. 2010), pp.1-17.
https://search.emarefa.net/detail/BIM-989164
American Medical Association (AMA)
Koraka, Penelope& Martina, Byron E. E.& Osterhaus, Albert D. M. E.. Bioinformatics in New Generation Flavivirus Vaccines. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-989164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989164