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Benchmarking B-Cell Epitope Prediction for the Design of Peptide-Based Vaccines: Problems and Prospects
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
To better support the design of peptide-based vaccines, refinement of methods to predict B-cell epitopes necessitates meaningful benchmarking against empirical data on the cross-reactivity of polyclonal antipeptide antibodies with proteins, such that the positive data reflect functionally relevant cross-reactivity (which is consistent with antibody-mediated change in protein function) and the negative data reflect genuine absence of cross-reactivity (rather than apparent absence of cross-reactivity due to artifactual masking of B-cell epitopes in immunoassays).
These data are heterogeneous in view of multiple factors that complicate B-cell epitope prediction, notably physicochemical factors that define key structural differences between immunizing peptides and their cognate proteins (e.g., unmatched electrical charges along the peptide-protein sequence alignments).
If the data are partitioned with respect to these factors, iterative parallel benchmarking against the resulting subsets of data provides a basis for systematically identifying and addressing the limitations of methods for B-cell epitope prediction as applied to vaccine design.
American Psychological Association (APA)
Caoili, Salvador Eugenio C.. 2010. Benchmarking B-Cell Epitope Prediction for the Design of Peptide-Based Vaccines: Problems and Prospects. BioMed Research International،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-989182
Modern Language Association (MLA)
Caoili, Salvador Eugenio C.. Benchmarking B-Cell Epitope Prediction for the Design of Peptide-Based Vaccines: Problems and Prospects. BioMed Research International No. 2010 (Dec. 2010), pp.1-14.
https://search.emarefa.net/detail/BIM-989182
American Medical Association (AMA)
Caoili, Salvador Eugenio C.. Benchmarking B-Cell Epitope Prediction for the Design of Peptide-Based Vaccines: Problems and Prospects. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-989182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989182