The Receptor for Advanced Glycation End Products (RAGE) and the Lung
Joint Authors
Ehrhardt, Carsten
Buckley, Stephen T.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules.
As a pattern-recognition receptor capable of binding a diverse range of ligands, it is typically expressed at low levels under normal physiological conditions in the majority of tissues.
In contrast, the lung exhibits high basal level expression of RAGE localised primarily in alveolar type I (ATI) cells, suggesting a potentially important role for the receptor in maintaining lung homeostasis.
Indeed, disruption of RAGE levels has been implicated in the pathogenesis of a variety of pulmonary disorders including cancer and fibrosis.
Furthermore, its soluble isoforms, sRAGE, which act as decoy receptors, have been shown to be a useful marker of ATI cell injury.
Whilst RAGE undoubtedly plays an important role in the biology of the lung, it remains unclear as to the exact nature of this contribution under both physiological and pathological conditions.
American Psychological Association (APA)
Buckley, Stephen T.& Ehrhardt, Carsten. 2009. The Receptor for Advanced Glycation End Products (RAGE) and the Lung. BioMed Research International،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989186
Modern Language Association (MLA)
Buckley, Stephen T.& Ehrhardt, Carsten. The Receptor for Advanced Glycation End Products (RAGE) and the Lung. BioMed Research International No. 2010 (Dec. 2010), pp.1-11.
https://search.emarefa.net/detail/BIM-989186
American Medical Association (AMA)
Buckley, Stephen T.& Ehrhardt, Carsten. The Receptor for Advanced Glycation End Products (RAGE) and the Lung. BioMed Research International. 2009. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989186