Temporal Adaptive Changes in Contractility and Fatigability of Diaphragm Muscles from Streptozotocin-Diabetic Rats
Joint Authors
Nosek, Thomas M.
Jin, J.-P.
Brotto, Marco
Romani, Andrea
Brotto, Leticia
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diabetes is characterized by ventilatory depression due to decreased diaphragm (DPH) function.
This study investigated the changes in contractile properties of rat DPH muscles over a time interval encompassing from 4 days to 14 weeks after the onset of streptozotocin-induced diabetes, with and without insulin treatment for 2 weeks.
Maximum tetanic force in intact DPH muscle strips and recovery from fatiguing stimulation were measured.
An early (4-day) depression in contractile function in diabetic DPH was followed by gradual improvement in muscle function and fatigue recovery (8 weeks).
DPH contractile function deteriorated again at 14 weeks, a process that was completely reversed by insulin treatment.
Maximal contractile force and calcium sensitivity assessed in Triton-skinned DPH fibers showed a similar bimodal pattern and the same beneficial effect of insulin treatment.
While an extensive analysis of the isoforms of the contractile and regulatory proteins was not conducted, Western blot analysis of tropomyosin suggests that the changes in diabetic DPH response depended, at least in part, on a switch in fiber type.
American Psychological Association (APA)
Brotto, Marco& Brotto, Leticia& Jin, J.-P.& Nosek, Thomas M.& Romani, Andrea. 2010. Temporal Adaptive Changes in Contractility and Fatigability of Diaphragm Muscles from Streptozotocin-Diabetic Rats. BioMed Research International،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989191
Modern Language Association (MLA)
Brotto, Marco…[et al.]. Temporal Adaptive Changes in Contractility and Fatigability of Diaphragm Muscles from Streptozotocin-Diabetic Rats. BioMed Research International No. 2010 (Dec. 2010), pp.1-8.
https://search.emarefa.net/detail/BIM-989191
American Medical Association (AMA)
Brotto, Marco& Brotto, Leticia& Jin, J.-P.& Nosek, Thomas M.& Romani, Andrea. Temporal Adaptive Changes in Contractility and Fatigability of Diaphragm Muscles from Streptozotocin-Diabetic Rats. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989191