IL-17 in Systemic Lupus Erythematosus
Joint Authors
Crispín, José C.
Tsokos, George C.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
IL-17 is a cytokine with powerful proinflammatory activity.
Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease.
In patients with SLE, CD3+CD4−CD8− (double negative) T cells are an important source of IL-17.
IL-17 produced by double negative and CD4 T cells participates in the pathogenesis of the disease.
IL-17-producing T cells are present in the kidneys of patients with lupus nephritis.
IL-17 increased production in patients with SLE can amplify the immune response by increasing target organ inflammation and damage and by augmenting the production of antibodies by B cells.
American Psychological Association (APA)
Crispín, José C.& Tsokos, George C.. 2010. IL-17 in Systemic Lupus Erythematosus. BioMed Research International،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-989199
Modern Language Association (MLA)
Crispín, José C.& Tsokos, George C.. IL-17 in Systemic Lupus Erythematosus. BioMed Research International No. 2010 (Dec. 2010), pp.1-4.
https://search.emarefa.net/detail/BIM-989199
American Medical Association (AMA)
Crispín, José C.& Tsokos, George C.. IL-17 in Systemic Lupus Erythematosus. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-989199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989199
