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A Method for Individualizing the Prediction of Immunogenicity of Protein Vaccines and Biologic Therapeutics: Individualized T Cell Epitope Measure (iTEM)
Joint Authors
Ardito, Matthew
Martin, William
Moise, Leonard
Cohen, Tobias
De Groot, Anne S.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The promise of pharmacogenomics depends on advancing predictive medicine.
To address this need in the area of immunology, we developed the individualized T cell epitope measure (iTEM) tool to estimate an individual's T cell response to a protein antigen based on HLA binding predictions.
In this study, we validated prospective iTEM predictions using data from in vitro and in vivo studies.
We used a mathematical formula that converts DRB1∗ allele binding predictions generated by EpiMatrix, an epitope-mapping tool, into an allele-specific scoring system.
We then demonstrated that iTEM can be used to define an HLA binding threshold above which immune response is likely and below which immune response is likely to be absent.
iTEM's predictive power was strongest when the immune response is focused, such as in subunit vaccination and administration of protein therapeutics.
iTEM may be a useful tool for clinical trial design and preclinical evaluation of vaccines and protein therapeutics.
American Psychological Association (APA)
Cohen, Tobias& Moise, Leonard& Ardito, Matthew& Martin, William& De Groot, Anne S.. 2010. A Method for Individualizing the Prediction of Immunogenicity of Protein Vaccines and Biologic Therapeutics: Individualized T Cell Epitope Measure (iTEM). BioMed Research International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-989210
Modern Language Association (MLA)
Cohen, Tobias…[et al.]. A Method for Individualizing the Prediction of Immunogenicity of Protein Vaccines and Biologic Therapeutics: Individualized T Cell Epitope Measure (iTEM). BioMed Research International No. 2010 (Dec. 2010), pp.1-7.
https://search.emarefa.net/detail/BIM-989210
American Medical Association (AMA)
Cohen, Tobias& Moise, Leonard& Ardito, Matthew& Martin, William& De Groot, Anne S.. A Method for Individualizing the Prediction of Immunogenicity of Protein Vaccines and Biologic Therapeutics: Individualized T Cell Epitope Measure (iTEM). BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-989210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989210