New Insights into the Structural Roles of Nebulin in Skeletal Muscle
Joint Authors
Ottenheijm, Coen A. C.
Granzier, Henk L. M.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
One important feature of muscle structure and function that has remained relatively obscure is the mechanism that regulates thin filament length.
Filament length is an important aspect of muscle function as force production is proportional to the amount of overlap between thick and thin filaments.
Recent advances, due in part to the generation of nebulin KO models, reveal that nebulin plays an important role in the regulation of thin filament length.
Another structural feature of skeletal muscle that is not well understood is the mechanism involved in maintaining the regular lateral alignment of adjacent sarcomeres, that is, myofibrillar connectivity.
Recent studies indicate that nebulin is part of a protein complex that mechanically links adjacent myofibrils.
Thus, novel structural roles of nebulin in skeletal muscle involve the regulation of thin filament length and maintaining myofibrillar connectivity.
When these functions of nebulin are absent, muscle weakness ensues, as is the case in patients with nemaline myopathy with mutations in nebulin.
Here we review these new insights in the role of nebulin in skeletal muscle structure.
American Psychological Association (APA)
Ottenheijm, Coen A. C.& Granzier, Henk L. M.. 2010. New Insights into the Structural Roles of Nebulin in Skeletal Muscle. BioMed Research International،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-989211
Modern Language Association (MLA)
Ottenheijm, Coen A. C.& Granzier, Henk L. M.. New Insights into the Structural Roles of Nebulin in Skeletal Muscle. BioMed Research International No. 2010 (Dec. 2010), pp.1-6.
https://search.emarefa.net/detail/BIM-989211
American Medical Association (AMA)
Ottenheijm, Coen A. C.& Granzier, Henk L. M.. New Insights into the Structural Roles of Nebulin in Skeletal Muscle. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-989211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989211