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Liver Development, Regeneration, and Carcinogenesis
Joint Authors
Kung, Janet W. C.
Ross, James A.
Forbes, Stuart J.
Currie, Ian S.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis.
Significant overlaps in the regulation of these processes are now being described.
For example, studies in embryonic liver development have already provided the basis for directed differentiation of human embryonic stem cells and induced pluripotent stem cells into hepatocyte-like cells.
As a result, the understanding of the cell biology of proliferation and differentiation in the liver has been improved.
This knowledge can be used to improve the function of hepatocyte-like cells for drug testing, bioartificial livers, and transplantation.
In parallel, the mechanisms regulating cancer cell biology are now clearer, providing fertile soil for novel therapeutic approaches.
Recognition of the relationships between development, regeneration, and carcinogenesis, and the increasing evidence for the role of stem cells in all of these areas, has sparked fresh enthusiasm in understanding the underlying molecular mechanisms and has led to new targeted therapies for liver cirrhosis and primary liver cancers.
American Psychological Association (APA)
Kung, Janet W. C.& Currie, Ian S.& Forbes, Stuart J.& Ross, James A.. 2010. Liver Development, Regeneration, and Carcinogenesis. BioMed Research International،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989219
Modern Language Association (MLA)
Kung, Janet W. C.…[et al.]. Liver Development, Regeneration, and Carcinogenesis. BioMed Research International No. 2010 (Dec. 2010), pp.1-8.
https://search.emarefa.net/detail/BIM-989219
American Medical Association (AMA)
Kung, Janet W. C.& Currie, Ian S.& Forbes, Stuart J.& Ross, James A.. Liver Development, Regeneration, and Carcinogenesis. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989219