In Vivo Cytogenetic Studies on Aspartame
Author
Source
International Journal of Genomics
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Aspartame (a-Laspartyl-L-phenylalanine 1-methylester) is a dipeptide low-calorie artificial sweetener that is widely used as a nonnutritive sweetener in foods and drinks.
The safety of aspartame and its metabolic breakdown products (phenylalanine, aspartic acid and methanol) was investigated in vivo using chromosomal aberration (CA) test and sister chromatid exchange (SCE) test in the bone marrow cells of mice.
Swiss Albino male mice were exposed to aspartame (3.5, 35, 350 mg/kg body weight).
Bone marrow cells isolated from femora were analyzed for chromosome aberrations and sister chromatid exchanges.
Treatment with aspartame induced dose dependently chromosome aberrations at all concentrations while it did not induce sister chromatid exchanges.
On the other hand, aspartame did not decrease the mitotic index (MI).
However, statistical analysis of the results show that aspartame is not significantly genotoxic at low concentration.
American Psychological Association (APA)
AlSuhaibani, Entissar S.. 2010. In Vivo Cytogenetic Studies on Aspartame. International Journal of Genomics،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-989234
Modern Language Association (MLA)
AlSuhaibani, Entissar S.. In Vivo Cytogenetic Studies on Aspartame. International Journal of Genomics No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-989234
American Medical Association (AMA)
AlSuhaibani, Entissar S.. In Vivo Cytogenetic Studies on Aspartame. International Journal of Genomics. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-989234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989234