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Therapeutics of Diabetes Mellitus: Focus on Insulin Analogues and Insulin Pumps
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aim.
Inadequately controlled diabetes accounts for chronic complications and increases mortality.
Its therapeutic management aims in normal HbA1C, prandial and postprandial glucose levels.
This review discusses diabetes management focusing on the latest insulin analogues, alternative insulin delivery systems and the artificial pancreas.
Results.
Intensive insulin therapy with multiple daily injections (MDI) allows better imitation of the physiological rhythm of insulin secretion.
Longer-acting, basal insulin analogues provide concomitant improvements in safety, efficacy and variability of glycaemic control, followed by low risks of hypoglycaemia.
Continuous subcutaneous insulin infusion (CSII) provides long-term glycaemic control especially in type 1 diabetic patients, while reducing hypoglycaemic episodes and glycaemic variability.
Continuous subcutaneous glucose monitoring (CGM) systems provide information on postprandial glucose excursions and nocturnal hypo- and/or hyperglycemias.
This information enhances treatment options, provides a useful tool for self-monitoring and allows safer achievement of treatment targets.
In the absence of a cure-like pancreas or islets transplants, artificial “closed-loop” systems mimicking the pancreatic activity have been also developed.
Conclusions.
Individualized treatment plans for insulin initiation and administration mode are critical in achieving target glycaemic levels.
Progress in these fields is expected to facilitate and improve the quality of life of diabetic patients.
American Psychological Association (APA)
Valla, Vasiliki. 2010. Therapeutics of Diabetes Mellitus: Focus on Insulin Analogues and Insulin Pumps. Journal of Diabetes Research،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-989269
Modern Language Association (MLA)
Valla, Vasiliki. Therapeutics of Diabetes Mellitus: Focus on Insulin Analogues and Insulin Pumps. Journal of Diabetes Research No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-989269
American Medical Association (AMA)
Valla, Vasiliki. Therapeutics of Diabetes Mellitus: Focus on Insulin Analogues and Insulin Pumps. Journal of Diabetes Research. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-989269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989269