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Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes: A Comparative Study
Joint Authors
Pfeilschifter, Josef
Müller, Elke
Schürmann, Christoph
Frank, Stefan
Goren, Itamar
Hermes, Nadine
Seitz, Oliver
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
In the past, the genetically diabetic-obese diabetes/diabetes (db/db) and obese/obese (ob/ob) mouse strains were used to investigate mechanisms of diabetes-impaired wound healing.
Here we determined patterns of skin repair in genetically normal C57Bl/6J mice that were fed using a high fat diet (HFD) to induce a diabetes-obesity syndrome.
Wound closure was markedly delayed in HFD-fed mice compared to mice which had received a standard chow diet (CD).
Impaired wound tissue of HFD mice showed a marked prolongation of wound inflammation.
Expression of vascular endothelial growth factor (VEGF) was delayed and associated with the disturbed formation of wound margin epithelia and an impaired angiogenesis in the reduced granulation tissue.
Normal wound contraction was retarded and disordered.
Wound disorders in obese C57Bl/6J mice were paralleled by a prominent degradation of the inhibitor of NFκB (IκB-α) in the absence of an Akt activation.
By contrast to impaired wound conditions in ob/ob mice, late wounds of HFD mice did not develop a chronic inflammatory state and were epithelialized after 11 days of repair.
Thus, only genetically obese and diabetic ob/ob mice finally developed chronic wounds and therefore represent a better suited experimental model to investigate diabetes-induced wound healing disorders.
American Psychological Association (APA)
Seitz, Oliver& Schürmann, Christoph& Hermes, Nadine& Müller, Elke& Pfeilschifter, Josef& Frank, Stefan…[et al.]. 2010. Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes: A Comparative Study. Journal of Diabetes Research،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-989273
Modern Language Association (MLA)
Seitz, Oliver…[et al.]. Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes: A Comparative Study. Journal of Diabetes Research No. 2010 (2010), pp.1-15.
https://search.emarefa.net/detail/BIM-989273
American Medical Association (AMA)
Seitz, Oliver& Schürmann, Christoph& Hermes, Nadine& Müller, Elke& Pfeilschifter, Josef& Frank, Stefan…[et al.]. Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes: A Comparative Study. Journal of Diabetes Research. 2010. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-989273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989273