Iron Overload in Diabetic Retinopathy: A Cause or a Consequence of Impaired Mechanisms?
Joint Authors
Ciudin, Andreea
Simó, Rafael
Hernández, Cristina
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Iron is an essential ion for life, playing a central role in many metabolic processes.
The most important property of free iron is its capacity to be reversibly oxidized and reduced, but at same time this make it highly pro-oxidant molecule.
In this regard, iron is able to generate powerful reactive oxygen species (ROS).
For this reason, careful control on iron availability is central to the maintenance of normal cell function in the retina.
In the diabetic eye there is an impairment of iron homeostasis, thus leading to iron overload.
The mechanisms involved in this process include: (1) Destruction of heme molecules induced by hyperglycemia (2) Intraretinal and vitreal hemorrhages (3) Overexpression of the renin-angiotensin system.
The main consequences of iron overload are the following: (1) Retinal neurodegeneration due to the increase of oxidative stress (2) Increase of AGE-RAGE binding (3) Defective phagocytosis of retinal pigment epithelium, which generates the accumulation of autoantigens and the synthesis of proinflammatory cytokines.
Further studies addressed to explore not only the role of iron in the pathogenesis of diabetic retinopathy, but also to design novel therapeutic strategies based on the regulation of iron homeostasis are needed.
American Psychological Association (APA)
Ciudin, Andreea& Hernández, Cristina& Simó, Rafael. 2010. Iron Overload in Diabetic Retinopathy: A Cause or a Consequence of Impaired Mechanisms?. Journal of Diabetes Research،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989277
Modern Language Association (MLA)
Ciudin, Andreea…[et al.]. Iron Overload in Diabetic Retinopathy: A Cause or a Consequence of Impaired Mechanisms?. Journal of Diabetes Research No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-989277
American Medical Association (AMA)
Ciudin, Andreea& Hernández, Cristina& Simó, Rafael. Iron Overload in Diabetic Retinopathy: A Cause or a Consequence of Impaired Mechanisms?. Journal of Diabetes Research. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989277