Fenofibrate Treatment Enhances Antioxidant Status and Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats
Joint Authors
Sözmen, Eser Y.
Olukman, Murat
Ülker, Sibel
Sezer, Ebru Demirel
Çınar, Gülcihan Mehtap
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic endothelial dysfunction is accompanied by increased oxidative stress and upregulated proinflammatory and inflammatory mediators in the vasculature.
Activation of peroxisome proliferator-activated receptor-alpha (PPAR-α) results in antioxidant and anti-inflammatory effects.
This study was designed to investigate the effect of fenofibrate, a PPAR-α activator, on the endothelial dysfunction, oxidative stress, and inflammation in streptozotocin diabetic rats.
Diabetic rats received fenofibrate (150 mg kg−1 day−1) for 4 weeks.
Fenofibrate treatment restored the impaired endothelium-dependent relaxation and increased basal nitric oxide availability in diabetic aorta, enhanced erythrocyte/liver superoxide dismutase and catalase levels, ameliorated the abnormal serum/aortic thiobarbituric acid reactive substances, and prevented the increased aortic myeloperoxidase without a significant change in serum total cholesterol and triglyceride levels.
It did not affect the decreased total homocysteine level and the increased tumor necrosis factor-α level in the serum of diabetic rats.
Fenofibrate-induced prevention of the endothelial function seems to be related to its potential antioxidant and antiinflammatory activity.
American Psychological Association (APA)
Olukman, Murat& Sezer, Ebru Demirel& Ülker, Sibel& Sözmen, Eser Y.& Çınar, Gülcihan Mehtap. 2010. Fenofibrate Treatment Enhances Antioxidant Status and Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-989279
Modern Language Association (MLA)
Olukman, Murat…[et al.]. Fenofibrate Treatment Enhances Antioxidant Status and Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-989279
American Medical Association (AMA)
Olukman, Murat& Sezer, Ebru Demirel& Ülker, Sibel& Sözmen, Eser Y.& Çınar, Gülcihan Mehtap. Fenofibrate Treatment Enhances Antioxidant Status and Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-989279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989279