Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice

Joint Authors

Wang, Haoren
Hua, Xianxin
Yang, Yuqing

Source

Journal of Diabetes Research

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-12-12

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases
Medicine

Abstract EN

Diabetes ultimately results from an inadequate number of functional beta cells in the islets of Langerhans.

Enhancing proliferation of functional endogenous beta cells to treat diabetes remains underexplored.

Here, we report that excision of the Men1 gene, whose loss-of-function mutation leads to inherited multiple endocrine neoplasia type 1 (MEN1), rendered resistant to streptozotocin-induced hyperglycemia in a tamoxifen-inducible and temporally controlled Men1 excision mouse model as well as in a tissue-specific Men1 excision mouse model.

Men1 excision prevented mice from streptozotocin-induced hyperglycemia mainly through increasing the number of functional beta cells.

BrdU incorporation by beta cells, islet size, and circulating insulin levels were significantly increased in Men1-excised mice.

Membrane localization of glucose transporter 2 was largely preserved in Men1-excised beta cells, but not in Men1-expressing beta cells.

Our findings suggest that repression of menin, a protein encoded by the Men1 gene, might be a valuable means to maintain or increase the number of functional endogenous beta cells to prevent or ameliorate diabetes.

American Psychological Association (APA)

Yang, Yuqing& Wang, Haoren& Hua, Xianxin. 2010. Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice. Journal of Diabetes Research،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989281

Modern Language Association (MLA)

Yang, Yuqing…[et al.]. Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice. Journal of Diabetes Research No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-989281

American Medical Association (AMA)

Yang, Yuqing& Wang, Haoren& Hua, Xianxin. Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice. Journal of Diabetes Research. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989281

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-989281