Modulation of the Cellular Expression of Circulating Advanced Glycation End-Product Receptors in Type 2 Diabetic Nephropathy

Joint Authors

Harcourt, Brooke E.
Morley, Amy L.
Sourris, Karly C.
Davies, Michael J.
Forbes, Josephine M.
Baker, Scott T.
Yap, Felicia Y. T.
Jerums, George
Morgan, Philip E.
Penfold, Sally A.

Source

Journal of Diabetes Research

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-11-05

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Diseases
Medicine

Abstract EN

Advanced glycation end-products (AGEs) and their receptors are prominent contributors to diabetic kidney disease.

Methods.

Flow cytometry was used to measure the predictive capacity for kidney impairment of the AGE receptors RAGE, AGE-R1, and AGE-R3 on peripheral blood mononuclear cells (PBMCs) in experimental models of type 2 diabetes (T2DM) fed varied AGE containing diets and in obese type 2 diabetic and control human subjects.

Results.

Diets high in AGE content fed to diabetic mice decreased cell surface RAGE on PBMCs and in type 2 diabetic patients with renal impairment (RI).

All diabetic mice had elevated Albumin excretion rates (AERs), and high AGE fed dbdb mice had declining Glomerular filtration rate (GFR).

Cell surface AGE-R1 expression was also decreased by high AGE diets and with diabetes in dbdb mice and in humans with RI.

PBMC expression of AGE R3 was decreased in diabetic dbdb mice or with a low AGE diet.

Conclusions.

The most predictive PBMC profile for renal disease associated with T2DM was an increase in the cell surface expression of AGE-R1, in the context of a decrease in membranous RAGE expression in humans, which warrants further investigation as a biomarker for progressive DN in larger patient cohorts.

American Psychological Association (APA)

Sourris, Karly C.& Harcourt, Brooke E.& Penfold, Sally A.& Yap, Felicia Y. T.& Morley, Amy L.& Morgan, Philip E.…[et al.]. 2010. Modulation of the Cellular Expression of Circulating Advanced Glycation End-Product Receptors in Type 2 Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989282

Modern Language Association (MLA)

Sourris, Karly C.…[et al.]. Modulation of the Cellular Expression of Circulating Advanced Glycation End-Product Receptors in Type 2 Diabetic Nephropathy. Journal of Diabetes Research No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-989282

American Medical Association (AMA)

Sourris, Karly C.& Harcourt, Brooke E.& Penfold, Sally A.& Yap, Felicia Y. T.& Morley, Amy L.& Morgan, Philip E.…[et al.]. Modulation of the Cellular Expression of Circulating Advanced Glycation End-Product Receptors in Type 2 Diabetic Nephropathy. Journal of Diabetes Research. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989282

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-989282