Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity
Joint Authors
Nesbeth, Yolanda
Conejo-Garcia, Jose R.
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Adoptive T cell transfer therapy, the ex vivo activation, expansion, and subsequent administration of tumor-reactive T cells, is already the most effective therapy against certain types of cancer.
However, recent evidence in animal models and clinical trials suggests that host conditioning interventions tailored for some of the most aggressive and frequent epithelial cancers will be needed to maximize the benefit of this approach.
Similarly, the subsets, stage of differentiation, and ex vivo expansion procedure of tumor-reactive T cells to be adoptively transferred influence their in vivo effectiveness and may need to be adapted for different types of cancer and host conditioning interventions.
The effects of adoptively transferred tumor-reactive T cells on the mechanisms of endogenous (host-derived) antitumor immunity, and how to maximize their combined effects, are further discussed.
American Psychological Association (APA)
Nesbeth, Yolanda& Conejo-Garcia, Jose R.. 2010. Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989285
Modern Language Association (MLA)
Nesbeth, Yolanda& Conejo-Garcia, Jose R.. Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity. Journal of Immunology Research No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-989285
American Medical Association (AMA)
Nesbeth, Yolanda& Conejo-Garcia, Jose R.. Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989285