The Immune-Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Joint Authors
Zhang, Hong-Liang
Zhu, Jie
Wu, Jiang
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Apolipoprotein E (apoE) is a 34.2 kDa glycoprotein characterized by its wide tissue distribution and multiple functions.
The nonlipid-related properties of apoE include modulating inflammation and oxidation, suppressing T cell proliferation, regulating macrophage functions, and facilitating lipid antigen presentation by CD1 molecules to natural killer T (NKT) cells, and so forth.
Increasing studies have revealed that APOE ε allele might be associated with multiple sclerosis (MS), although evidence is still not sufficient enough.
In this review, we summarized the current progress of the immunomodulatory functions of apoE, with special focus on the association of APOE ε allele with the clinical features of MS and of its animal model experimental autoimmune encephalomyelitis (EAE).
American Psychological Association (APA)
Zhang, Hong-Liang& Wu, Jiang& Zhu, Jie. 2010. The Immune-Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-989290
Modern Language Association (MLA)
Zhang, Hong-Liang…[et al.]. The Immune-Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Journal of Immunology Research No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-989290
American Medical Association (AMA)
Zhang, Hong-Liang& Wu, Jiang& Zhu, Jie. The Immune-Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-989290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989290