Correlation between Clinicopathology and Expression of Heat Shock Protein 72 and Glycoprotein 96 in Human Esophageal Squamous Cell Carcinoma
Joint Authors
Wang, Qiaoxia
Lin, Huanping
Wang, Xiaoping
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues.
Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of gastrointestinal carcinomas but detailed information is still ambiguous.
We investigated the correlation between clinicopathology and expression of HSP72 and gp96 in human esophageal squamous cell carcinoma.
The expression of HSP72 and gp96 was studied in 120 human esophageal squamous cell carcinomas with or without metastasis as well as in mucous membrane adjacent to cancers by way of immunohistochemistry.
HSP72 immunoreactivities were detected in 112 of 120 primary tumors (93.3%) and in 30 of 120 mucous membranes adjacent to cancers (25.0%).
Gp96 detected in esophageal squamous cell carcinoma and inmucous membrane adjacent to cancer was 85.0% and 20.0%, respectively.
Both HSP72 and gp96 stained in cytoplasm.
HSP72 and gp96 expression in esophageal squamous cell carcinomas withmetastasis was significantly higher than those with nonmetastasis (P<.05).
The results indicate that there exists a significant correlation between the expression of HSP72 and gp96 and the progression of esophageal squamous cell carcinomas.
HSP72 and gp96 expression were significantly associated with the presence of tumor infiltration, lymph node, and remote metastasis.
American Psychological Association (APA)
Wang, Xiaoping& Wang, Qiaoxia& Lin, Huanping. 2010. Correlation between Clinicopathology and Expression of Heat Shock Protein 72 and Glycoprotein 96 in Human Esophageal Squamous Cell Carcinoma. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989292
Modern Language Association (MLA)
Wang, Xiaoping…[et al.]. Correlation between Clinicopathology and Expression of Heat Shock Protein 72 and Glycoprotein 96 in Human Esophageal Squamous Cell Carcinoma. Journal of Immunology Research No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-989292
American Medical Association (AMA)
Wang, Xiaoping& Wang, Qiaoxia& Lin, Huanping. Correlation between Clinicopathology and Expression of Heat Shock Protein 72 and Glycoprotein 96 in Human Esophageal Squamous Cell Carcinoma. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989292