Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly Residents
Joint Authors
Trivello, Renzo
Baldovin, Tatjana
Angiolelli, Gabriele
Busana, Marta Cecilia
Pellegrini, Michele
Floreani, Annarosa
Bertoncello, Chiara
Baldo, Vincenzo
Majori, Silvia
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We studied whether MF59-adjuvanted influenza vaccine improves immunity against drifted influenza strains in institutionalised elderly with underling chronic health conditions.
Sera from a randomized study, comparing MF59-adjuvanted (Sub/MF59, n=72), virosomal (SVV, n=39), and split (n=88) vaccines, were retested using a hemagglutination inhibition (HI) assay against homologous (Northern Hemisphere [NH] 1998/99) and drifted (NH 2006/07) strains.
Corrected postvaccination HI antibody titres were significantly higher with Sub/MF59 than SVV for all strains; GMTs against homologous A/H3N2 and B and both drifted A strains were significantly higher for Sub/MF59 than split.
Seroprotection rates and mean-fold titer increases were generally higher with Sub/MF59 for all A influenza strains.
MF59-adjuvanted influenza vaccine induced greater and broader immune responses in elderly people with chronic conditions, than conventional virosomal and split vaccines, particularly for A/H1 and A/H3 strains, potentially giving clinical benefit in seasons where antigenic mismatch occurs.
American Psychological Association (APA)
Baldo, Vincenzo& Baldovin, Tatjana& Pellegrini, Michele& Angiolelli, Gabriele& Majori, Silvia& Floreani, Annarosa…[et al.]. 2010. Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly Residents. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989315
Modern Language Association (MLA)
Baldo, Vincenzo…[et al.]. Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly Residents. Journal of Immunology Research No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-989315
American Medical Association (AMA)
Baldo, Vincenzo& Baldovin, Tatjana& Pellegrini, Michele& Angiolelli, Gabriele& Majori, Silvia& Floreani, Annarosa…[et al.]. Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly Residents. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-989315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989315