Tumor Antigen Cross-Presentation and the Dendritic Cell: Where it All Begins?
Joint Authors
Robinson, Bruce W. S.
McDonnell, Alison M.
Currie, Andrew J.
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts, which may limit their capacity to mount an effective tumor-specific CTL response.
In particular, the manner in which exogenous tumor antigens are acquired, processed, and cross-presented to CD8 T cells by DCs in tumor-bearing hosts is not well understood, but may have a profound effect on antitumor immunity.
In this paper, we have examined the role of DCs in the cross-presentation of tumor antigen in terms of their subset, function, migration, and location with the intention of examining the early processes that contribute to the development of an ineffective anti-tumor immune response.
American Psychological Association (APA)
McDonnell, Alison M.& Robinson, Bruce W. S.& Currie, Andrew J.. 2010. Tumor Antigen Cross-Presentation and the Dendritic Cell: Where it All Begins?. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989318
Modern Language Association (MLA)
McDonnell, Alison M.…[et al.]. Tumor Antigen Cross-Presentation and the Dendritic Cell: Where it All Begins?. Journal of Immunology Research No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-989318
American Medical Association (AMA)
McDonnell, Alison M.& Robinson, Bruce W. S.& Currie, Andrew J.. Tumor Antigen Cross-Presentation and the Dendritic Cell: Where it All Begins?. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989318