The Role of SykCARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections

Joint Authors

Brown, Gordon D.
Marakalala, Mohlopheni Jackson
Graham, Lisa M.

Source

Journal of Immunology Research

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-12-20

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

There is increasing interest in understanding the mechanisms underlying the interactions that occur between Mycobacterium tuberculosis and host innate immune cells.

These cells express pattern recognition receptors (PRRs) which recognise mycobacterial pathogen-associated molecular patterns (PAMPs) and which can influence the host immune response to the infection.

Although many of the PRRs appear to be redundant in the control of M.

tuberculosis infection in vivo, recent discoveries have revealed a key, nonredundant, role of the Syk/CARD9 signalling pathway in antimycobacterial immunity.

Here we review these discoveries, as well as recent data investigating the role of the Syk/CARD9-coupled PRRs that have been implicated in mycobacterial recognition, including Dectin-1 and Mincle.

American Psychological Association (APA)

Marakalala, Mohlopheni Jackson& Graham, Lisa M.& Brown, Gordon D.. 2010. The Role of SykCARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989321

Modern Language Association (MLA)

Marakalala, Mohlopheni Jackson…[et al.]. The Role of SykCARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections. Journal of Immunology Research No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-989321

American Medical Association (AMA)

Marakalala, Mohlopheni Jackson& Graham, Lisa M.& Brown, Gordon D.. The Role of SykCARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989321

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-989321