Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27
Joint Authors
Mizoguchi, Izuru
Xu, Mingli
Mizuguchi, Junichiro
Yoshimoto, Takayuki
Morishima, Noriko
Chiba, Yukino
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The interleukin (IL)-12 family, which is composed of heterodimeric cytokines including IL-12, IL-23, and IL-27, is produced by antigen-presenting cells such as macrophages and dendritic cells and plays critical roles in the regulation of helper T (Th) cell differentiation.
IL-12 induces IFN-γ production by NK and T cells and differentiation to Th1 cells.
IL-23 induces IL-17 production by memory T cells and expands and maintains inflammatory Th17 cells.
IL-27 induces the early Th1 differentiation and generation of IL-10-producing regulatory T cells.
In addition, these cytokines induce distinct immune responses to tumors.
IL-12 activates signal transducers and activator of transcription (STAT)4 and enhances antitumor cellular immunity through interferon (IFN)-γ production.
IL-27 activates STAT1, as does IFN-γ and STAT3 as well, and enhances antitumor immunity by augmenting cellular and humoral immunities.
In contrast, although exogenously overexpressed IL-23 enhances antitumor immunity via memory T cells, endogenous IL-23 promotes protumor immunity through STAT3 activation by inducing inflammatory responses including IL-17 production.
American Psychological Association (APA)
Xu, Mingli& Mizoguchi, Izuru& Morishima, Noriko& Chiba, Yukino& Mizuguchi, Junichiro& Yoshimoto, Takayuki. 2010. Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989337
Modern Language Association (MLA)
Xu, Mingli…[et al.]. Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27. Journal of Immunology Research No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-989337
American Medical Association (AMA)
Xu, Mingli& Mizoguchi, Izuru& Morishima, Noriko& Chiba, Yukino& Mizuguchi, Junichiro& Yoshimoto, Takayuki. Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989337