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Interleukin-15 Affects Patient Survival through Natural Killer Cell Recovery after Autologous Hematopoietic Stem Cell Transplantation for Non-Hodgkin Lymphomas
Joint Authors
Inwards, David J.
Ansell, Stephen M.
Johnston, Patrick B.
Micallef, Ivana N.
Porrata, Luis F.
Markovic, Svetomir N.
Hogan, William J.
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Natural killer cells at day 15 (NK-15), after autologous peripheral blood hematopoietic stem cell transplantation (APHSCT), is a prognostic factor for overall survival (OS) and progression-free survival (PFS) in non-Hodgkin lymphoma (NHL).
The potential role of the immunologic (homeostatic) environment affecting NK-15 recovery and survival post-APHSCT has not been fully studied.
Therefore, we evaluate prospectively the cytokine profile in 50 NHL patients treated with APHSCT.
Patients with an interleukin-15 (IL-15)≥76.5 pg/mL at day 15 post-APHSCT experienced superior OS and PFS compared with those who did not; median OS; not reached versus 19.2 months, P<.002; and median PFS; not reached versus 6.8 months, P<.002, respectively.
IL-15 was found to correlate with (rs=0.7, P<.0001) NK-15.
Multivariate analysis showed only NK-15 as a prognostic factor for survival, suggesting that the survival benefit observed by IL-15 is most likely mediated by enhanced NK cell recovery post-APHSCT.
American Psychological Association (APA)
Porrata, Luis F.& Inwards, David J.& Micallef, Ivana N.& Johnston, Patrick B.& Ansell, Stephen M.& Hogan, William J.…[et al.]. 2010. Interleukin-15 Affects Patient Survival through Natural Killer Cell Recovery after Autologous Hematopoietic Stem Cell Transplantation for Non-Hodgkin Lymphomas. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-989340
Modern Language Association (MLA)
Porrata, Luis F.…[et al.]. Interleukin-15 Affects Patient Survival through Natural Killer Cell Recovery after Autologous Hematopoietic Stem Cell Transplantation for Non-Hodgkin Lymphomas. Journal of Immunology Research No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-989340
American Medical Association (AMA)
Porrata, Luis F.& Inwards, David J.& Micallef, Ivana N.& Johnston, Patrick B.& Ansell, Stephen M.& Hogan, William J.…[et al.]. Interleukin-15 Affects Patient Survival through Natural Killer Cell Recovery after Autologous Hematopoietic Stem Cell Transplantation for Non-Hodgkin Lymphomas. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-989340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989340