Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR23 Receptors in a Rodent Model of Parkinson's Disease
Joint Authors
Vernon, Anthony C.
Datla, Krishna P.
Dexter, David T.
Croucher, Martin J.
Zabarsky, Virginia
Chan, Hugh
Paur, Helen
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Clinical trials have demonstrated positive proof of efficacy of dual metabotropic glutamate receptor 2/3 (mGluR2/3) agonists in both anxiety and schizophrenia.
Importantly, evidence suggests that these drugs may also be neuroprotective against glutamate excitotoxicity, implicated in the pathogenesis of Parkinson's disease (PD).
However, whether this neuroprotection also translates into functional recovery is unclear.
In the current study, we examined the neuroprotective efficacy of the dual mGluR2/3 agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC), and whether this is accompanied by behavioral recovery in a rodent 6-hydroxydopamine (6-OHDA) model of PD.
We now report that delayed post lesion treatment with 2R,4R-APDC (10 nmol), results in robust neuroprotection of the nigrostriatal system, which translated into functional recovery as measured by improved forelimb use asymmetry and reduced (+)-amphetamine-induced rotation compared to vehicle treated animals.
Interestingly, these beneficial effects were associated with a decrease in microglial markers in the SNc, which may suggest an antiinflammatory action of this drug.
American Psychological Association (APA)
Chan, Hugh& Paur, Helen& Vernon, Anthony C.& Zabarsky, Virginia& Datla, Krishna P.& Croucher, Martin J.…[et al.]. 2010. Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR23 Receptors in a Rodent Model of Parkinson's Disease. Parkinson’s Disease،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989695
Modern Language Association (MLA)
Chan, Hugh…[et al.]. Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR23 Receptors in a Rodent Model of Parkinson's Disease. Parkinson’s Disease No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-989695
American Medical Association (AMA)
Chan, Hugh& Paur, Helen& Vernon, Anthony C.& Zabarsky, Virginia& Datla, Krishna P.& Croucher, Martin J.…[et al.]. Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR23 Receptors in a Rodent Model of Parkinson's Disease. Parkinson’s Disease. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989695